Nanomedicine Lab @ICN2

Small, 2023, in press

Lung persistence, biodegradation and elimination of graphene based materials is predominantly size-dependent and mediated by alveolar phagocytes

Thomas Loret^, Luis Visani de Luna^, Matteo Lucherelli, Alexander Fordham, Neus Lozano, Alberto Bianco*, Kostas Kostarelos*, Cyrill Bussy*

FULL ABSTRACT

ACS Nano 2023, 17 (3): 1965–1978

Graphene oxide nanosheets reduce astrocyte reactivity to inflammation and ameliorate experimental autoimmune encephalomyelitis

Giuseppe Di Mauro, Roberta Amoriello, Neus Lozano, Alberto Carnasciali, Daniele Guasti, Maurizio Becucci, Giada Cellot*, Kostas Kostarelos, Clara Ballerini*, Laura Ballerini*

FULL ABSTRACT

Nature Nanotechnology, 2023, 18 (1): 42-48

Graphene oxide elicits microbiome-dependent type 2 immune responses via the aryl hydrocarbon receptor

Guotao Peng, Hanna Sinkko, Harri Alenius, Neus Lozano, Kostas Kostarelos, Lars Bräutigam, Bengt Fadeel*

FULL ABSTRACT

Nanoscale, 2022, 14 (46): 17297-17314

Graphene oxide modulates dendritic cell ability to promote T cell activation and cytokine production

Helen Parker, Alfredo Gravagnuolo, Sandra Vranic, Livia Crica, Leon Newman, Oliver Carnell, Cyrill Bussy, Rebecca Dookie, Eric Prestat, Sarah Haigh, Neus Lozano, Kostas Kostarelos*, Andrew MacDonald*

FULL ABSTRACT

Advanced Healthcare Materials, 2022, 2201968

Graphene oxide nanoscale platform enhances the anti-cancer properties of bortezomib in glioblastoma models

Paul Sharp^, Maria Stylianou^, Luis Arellano, Juliana Neves, Alfredo Gravagnuolo, Abbie Dodd, Katharine Barr, Neus Lozano, Thomas Kisby*, Kostas Kostarelos*

FULL ABSTRACT

Particle and Fibre Toxicology, 2022, 19 (1), 1-21

Lung recovery from DNA damage induced by graphene oxide is dependent on size, dose and inflammation profile

Luis Augusto Visani de Luna, Thomas Loret, Alexander Fordham, Atta Arshad, Matthew Drummond, Abbie Dodd, Neus Lozano, Kostas Kostarelos and Cyrill Bussy

FULL ABSTRACT

Advanced Science, 2022, 9, 2104559

Innate but not adaptive immunity regulates lung recovery from chronic exposure to graphene oxide nanosheets

Thomas Loret, Luis Luna, Alexander Fordham, Atta Arshad, Katharine Barr, Neus Lozano, Kostas Kostarelos and Cyrill Bussy

FULL ABSTRACT

Journal of Controlled Release, 2021, 338, 330-340

The impact of graphene oxide sheet lateral dimensions on their pharmacokinetic and tissue distribution profiles in mice

Dhifaf Jasim, Leon Newman, Artur Filipe Rodrigues, Isabella A. Vacchi, Matteo A. Lucherelli, Neus Lozano, Cécilia Ménard-Moyon, Alberto Bianco, Kostas Kostarelos*

FULL ABSTRACT

Small, 2021, 17 (25), 2101483

Graphene oxide nanosheets interact and interfere with SARS-CoV-2 surface proteins and cell receptors to inhibit infectivity

Mehmet Altay Unal, Fatma Bayrakdar, Hasan Nazir, Omur Besbinar, Cansu Gurcan, Neus Lozano, Luis Arellano, Süleyman Yalcin, Oguzhan Panatli, Dogantan Celik, Damla Alkaya, Aydan Agan, Laura Fusco, Serap Yildiz, Lucia Delogu, Kamil Akcali, Kostas Kostarelos,* Açelya Yilmazer*

FULL ABSTRACT

Carbon, 2021, 176, 458-469

Shedding plasma membrane vesicles induced by graphene oxide nanoflakes in brain cultured astrocytes

Mattia Musto, Pietro Parisse, Maria Pachetti, Christian Memo, Giuseppe Di Mauro, Belen Ballesteros, Neus Lozano, Kostas Kostarelos, Loredana Casalis*, Laura Ballerini*

FULL ABSTRACT

Biomaterials, 2021, 271, 120749

Graphene oxide prevents lateral amygdala dysfunctional synaptic plasticity and reverts long lasting anxiety behavior in rats

Audrey F. Biagioni, Giada Cellot, Elisa Pati, Neus Lozano, Belén Ballesteros, Raffaele Casani, Norberto C. Coimbra, Kostas Kostarelos, Laura Ballerini*

FULL ABSTRACT

Small, 2020, 16 (48), 2004029

Intracerebral injection of graphene oxide nanosheets mitigates microglial activation without inducing acute neurotoxicity: A pilot comparison to other nanomaterials

Corinne Portioli, Cyrill Bussy*, Mariarosa Mazza, Neus Lozano, Dhifaf A. Jasim, Maurizio Prato, Alberto Bianco, Marina Bentivoglio, Kostas Kostarelos*

FULL ABSTRACT

FlatChem 2018, 12, 17-25

Graphene-based papers as substrates for cell growth: Characterisation and impact on mammalian cells

Dhifaf Jasim, Neus Lozano, Cyrill Bussy, Irina Barbolina, Artur Filipe Rodrigues, Kostya Novoselov, Kostas Kostarelos*

FULL ABSTRACT

2D Materials, 2018, 5, 035020

A blueprint for the synthesis and characterisation of thin graphene oxide with controlled lateral dimensions for biomedicine

Artur Rodrigues, Leon Newman, Neus Lozano, Sourav Mukherjee, Bengt Fadeel, Cyrill Bussy*, Kostas Kostarelos*

FULL ABSTRACT

Chem, 2018, 4 (2), 334-358

Graphene oxide elicits membrane lipid changes and neutrophil extracellular trap formation

Sourav Mukherjee, Beatrice Lazzaretto, Kjell Hultenby, Leon Newman, Artur Rodrigues, Neus Lozano, Kostas Kostarelos, Per Malmberg, and Bengt Fadeel*

FULL ABSTRACT

npj 2D Materials and Applications, 2017, 39

Hypochlorite degrades 2D graphene oxide sheets faster than 1D oxidised carbon nanotubes and nanohorns

Leon Newman, Neus Lozano, Minfang Zhang, Sumio Iijima, Masako Yudasaka, Cyrill Bussy* and Kostas Kostarelos*

FULL ABSTRACT

Advanced Healthcare Materials, 2017, 6 (21), 1700374

Liposome-indocyanine green nanoprobes for optical labelling and tracking of human mesenchymal stem cells post-transplantation in vivo

Mariarosa Mazza, Neus Lozano, Debora Braga Vieira, Maurizio Buggio, Cay Kielty, Kostas Kostarelos*

FULL ABSTRACT

PLoS One, 2016, 11 (11), e0166816

Detection of endotoxin contamination of graphene-based materials using the TNF-α expression test and guidelines for endotoxin-free graphene oxide production

Sourav Mukherjee, Neus Lozano, Melanie Kucki, Antonio E. Del Rio-Castillo, Leon Newman, Ester Vázquez, Kostas Kostarelos, Peter Wick, Bengt Fadeel*

FULL ABSTRACT

International Journal of Pharmaceutics, 2016, 514 (1), 133-141

Engineering thermosensitive liposome-nanoparticle hybrids loaded with doxorubicin for heat-triggered drug release

Zahraa Al-Ahmady^, Neus Lozano^, Kuo-Ching Mei^, Wafa’ T. Al-Jamal, Kostas Kostarelos*

FULL ABSTRACT

2D Materials, 2016, 3 (2), 025025

Purity of graphene oxide determines its antibacterial activity

Irina Barbolina, Colin Woods, Neus Lozano, Kostas Kostarelos, Konstantin Novoselov, Ian Roberts*

FULL ABSTRACT

ACS Nano, 2016, 10 (4), 4459-4471

Graphene oxide nanosheets reshape synaptic function in cultured brain networks

Rossana Rauti, Neus Lozano, Verónica León, Denis Scaini, Mattia Musto, Ilaria Rago, Francesco Paolo Ulloa Severino, Alessandra Fabbro, Loredana Casalis, Ester Vázquez, Kostas Kostarelos, Maurizio Prato, and Laura Ballerini*

FULL ABSTRACT

2D Materials, 2016, 3 (1), 01406

Synthesis of few-layered, high-purity graphene oxide sheets from different graphite sources for biology

Dhifaf A. Jasim, Neus Lozano, Kostas Kostarelos*

FULL ABSTRACT

International Journal of Pharmaceutics, 2015, 482, 2-10

Monoclonal antibody-targeted PEGylated liposome-ICG encapsulating doxorubicin as a potential theranostic agent

Neus Lozano, Zahraa S. Al-Ahmady, Nicolas S. Beziere, Vasilis Ntziachristos*, Kostas Kostarelos*

FULL ABSTRACT

Nanoscale, 2015, 7, 6432-6435

The current graphene safety landscape – a literature mining exercise

Cyrill Bussy, Dhifaf A. Jasim, Neus Lozano, Daniel Terry, Kostas Kostarelos*

FULL ABSTRACT

Biomaterials, 2015, 37, 415-424

Dynamic imaging of PEGylated indocyanine green (ICG) liposomes within the tumor microenvironment using multi-spectral optoacoustic tomography (MSOT)

Nicolas Beziere^, Neus Lozano^, Antonio Nunes, Juan Salichs, Daniel Queiros, Kostas Kostarelos*, Vasilis Ntziachristos*

FULL ABSTRACT