Nanomedicine Lab @ICN2

Nature Reviews Chemistry, 2024, in press

The challenge and necessity of biological and environmental degradation for two-dimensional materials

Sandra Vranic^, Rajendra Kurapati^, Kostas Kostarelos*, Alberto Bianco*

FULL ABSTRACT

Nano Today, 2024, 56:102254

Functioning human lung organoids model pulmonary tissue response from carbon nanomaterial exposures

Rahaf Issa, Neus Lozano, Kostas Kostarelos, Sandra Vranic*

FULL ABSTRACT

Nature Reviews Materials, 2024, 1-4

In vivo biomolecule corona and the transformation of a foe into an ally for nanomedicine

Marilena Hadjidemetriou, Morteza Mahmoudi*, Kostas Kostarelos*

FULL ABSTRACT

Nature Nanotechnology, 2024, in press [https://doi.org/10.1038/s41565-023-01572-3]

First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses

Jack Andrews^, Shruti Joshi^, Evangelos Tzolos, Maaz Syed, Hayley Cuthbert, Livia Crica, Neus Lozano, Emmanuel Okwelogu, Jennifer Raftis, Lorraine Bruce, Craig Poland, Rodger Duffin, Paul Fokkens, John Boere, Daan Leseman, Ian Megson, Phil D. Whitfield, Kerstin Ziegler, Seshu Tammireddy, Marilena Hadjidemetriou, Cyrill Bussy, Flemming Cassee, David Newby, Kostas Kostarelos*, Mark Miller*

FULL ABSTRACT

Nanoscale, 2024, in press [https://pubs.rsc.org/en/content/articlehtml/2024/nr/d3nr06033k]

Graphene oxide activates canonical TGFβ signalling in a human chondrocyte cell line via increased plasma membrane tension

Leona Ogene, Steven Woods, Joseph Hetmanski, Neus Lozano, Angeliki Karakasidi, Patrick T. Caswell, Kostas Kostarelos, Marco Domingos, Sandra Vranic, Susan Kimber*

FULL ABSTRACT

ACS Nano, 2024, published online

Environmental and health impacts of graphene and other two-dimensional materials: a Graphene Flagship perspective

Hazel Lin, Tina Buerki-Thurnherr, Jasreen Kaur, Peter Wick, Marco Pelin, Aurelia Tubaro, Fabio Candotto Carniel, Mauro Tretiach, Emanuel Flahaut, Daniel Iglesias, Ester Vázquez, Giada Cellot, Laura Ballerini, Valentina Castagnola, Fabio Benfenati, Andrea Armirotti, Antoine Sallustrau, Mathilde Keck, Frédéric Taran, Cyrill Bussy, Sandra Vranic, Kostas Kostarelos, Mona Connolly, José Maria Navas, Florence Mouchet, Laury Gauthier, James Baker, Blanca Suarez-Merino, Tomi Kanerva, Maurizio Prato, Bengt Fadeel*, Alberto Bianco*

FULL ABSTRACT

Nature Reviews Electrical Engineering, 2024, in press

Clinical translation of graphene-based medical technology

Kostas Kostarelos, Carolina Aguilar, and Jose Garrido*

FULL ABSTRACT

Nature Nanotechnology 2024, in press [https://doi.org/10.1038/s41565-023-01570-5]

Nanoporous graphene-based thin-film microelectrodes for in vivo high-resolution neural recording and stimulation

Damià Viana^, Steven T. Walston^, Eduard Masvidal-Codina^, Xavier Illa, Bruno Rodríguez-Meana, Jaume del Valle, Andrew Hayward, Abbie Dodd, Thomas Loret, Elisabet Prats-Alfonso, Natàlia de la Oliva, Marie Palma, Elena del Corro, María del Pilar Bernicola, Elisa Rodríguez-Lucas, Thomas A. Gener, Jose Manuel de la Cruz, Miguel Torres-Miranda, Fikret Taygun Duvan, Nicola Ria, Justin Sperling, Sara Martí-Sánchez, Maria Chiara Spadaro, Clément Hébert, Sinead Savage, Jordi Arbiol, Anton Guimerà-Brunet, M. Victoria Puig, Blaise Yvert, Xavier Navarro, Kostas Kostarelos*, Jose A. Garrido*

FULL ABSTRACT

bioRxiv, 2024, doi.org/10.1101/2023.09.18.558196

Engineering the glioblastoma microenvironment using TLR7/8 agonist-complexed graphene oxide nanosheets

Maria Stylianou, Thomas Kisby*, Despoina Despotopoulou, Helen Parker, Alexandra Thawley, Kiana Arashvand, Neus Lozano, Andrew MacDonald, Kostas Kostarelos*

FULL ABSTRACT

Nanoscale, 2023, published online [https://doi.org/10.1039/D3NR04490D]

Delivery of graphene oxide nanosheets modulates glutamate release and normalizes amygdala synaptic plasticity to improve anxiety-related behavior

Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Neus Lozano, Kostas Kostarelos, Giada Cellot*, Laura Ballerini*

FULL ABSTRACT

Chemistry - A European Journal, 2023, e202301762

Graphene oxide nanosheets hamper glutamate mediated excitotoxicity and protect neuronal survival in an in vitro stroke model

Lorenza Tortella, Irene Santini, Neus Lozano, Kostas Kostarelos, Giada Cellot*, Laura Ballerini*

FULL ABSTRACT

bioRxiv, 2023, doi.org/10.1101/2023.08.22.553542

Engineering of a graphene oxide-based two-dimensional platform for immune activation and modulation

Despoina Despotopoulou, Maria Stylianou, Luis Miguel Arellano, Thomas Kisby, Neus Lozano, Kostas Kostarelos*

FULL ABSTRACT

Small, 2023,19, 2301201

Lung persistence, biodegradation and elimination of graphene based materials is predominantly size-dependent and mediated by alveolar phagocytes

Thomas Loret^, Luis Visani de Luna^, Matteo Lucherelli, Alexander Fordham, Neus Lozano, Alberto Bianco*, Kostas Kostarelos*, Cyrill Bussy*

FULL ABSTRACT

ACS Nano 2023, 17 (3): 1965–1978

Graphene oxide nanosheets reduce astrocyte reactivity to inflammation and ameliorate experimental autoimmune encephalomyelitis

Giuseppe Di Mauro, Roberta Amoriello, Neus Lozano, Alberto Carnasciali, Daniele Guasti, Maurizio Becucci, Giada Cellot*, Kostas Kostarelos, Clara Ballerini*, Laura Ballerini*

FULL ABSTRACT

Nature Nanotechnology, 2023, 18 (1): 42-48

Graphene oxide elicits microbiome-dependent type 2 immune responses via the aryl hydrocarbon receptor

Guotao Peng, Hanna Sinkko, Harri Alenius, Neus Lozano, Kostas Kostarelos, Lars Bräutigam, Bengt Fadeel*

FULL ABSTRACT

Nanoscale, 2022, 14 (46): 17297-17314

Graphene oxide modulates dendritic cell ability to promote T cell activation and cytokine production

Helen Parker, Alfredo Gravagnuolo, Sandra Vranic, Livia Crica, Leon Newman, Oliver Carnell, Cyrill Bussy, Rebecca Dookie, Eric Prestat, Sarah Haigh, Neus Lozano, Kostas Kostarelos*, Andrew MacDonald*

FULL ABSTRACT

Advanced Healthcare Materials, 2022, 2201968

Graphene oxide nanoscale platform enhances the anti-cancer properties of bortezomib in glioblastoma models

Paul Sharp^, Maria Stylianou^, Luis Arellano, Juliana Neves, Alfredo Gravagnuolo, Abbie Dodd, Katharine Barr, Neus Lozano, Thomas Kisby*, Kostas Kostarelos*

FULL ABSTRACT

Particle and Fibre Toxicology, 2022, 19 (1), 1-21

Lung recovery from DNA damage induced by graphene oxide is dependent on size, dose and inflammation profile

Luis Augusto Visani de Luna, Thomas Loret, Alexander Fordham, Atta Arshad, Matthew Drummond, Abbie Dodd, Neus Lozano, Kostas Kostarelos and Cyrill Bussy

FULL ABSTRACT

Advanced Science, 2022, 9, 2104559

Innate but not adaptive immunity regulates lung recovery from chronic exposure to graphene oxide nanosheets

Thomas Loret, Luis Luna, Alexander Fordham, Atta Arshad, Katharine Barr, Neus Lozano, Kostas Kostarelos and Cyrill Bussy

FULL ABSTRACT

Journal of Controlled Release, 2021, 338, 330-340

The impact of graphene oxide sheet lateral dimensions on their pharmacokinetic and tissue distribution profiles in mice

Dhifaf Jasim, Leon Newman, Artur Filipe Rodrigues, Isabella A. Vacchi, Matteo A. Lucherelli, Neus Lozano, Cécilia Ménard-Moyon, Alberto Bianco, Kostas Kostarelos*

FULL ABSTRACT

Small, 2021, 17 (25), 2101483

Graphene oxide nanosheets interact and interfere with SARS-CoV-2 surface proteins and cell receptors to inhibit infectivity

Mehmet Altay Unal, Fatma Bayrakdar, Hasan Nazir, Omur Besbinar, Cansu Gurcan, Neus Lozano, Luis Arellano, Süleyman Yalcin, Oguzhan Panatli, Dogantan Celik, Damla Alkaya, Aydan Agan, Laura Fusco, Serap Yildiz, Lucia Delogu, Kamil Akcali, Kostas Kostarelos,* Açelya Yilmazer*

FULL ABSTRACT

Carbon, 2021, 176, 458-469

Shedding plasma membrane vesicles induced by graphene oxide nanoflakes in brain cultured astrocytes

Mattia Musto, Pietro Parisse, Maria Pachetti, Christian Memo, Giuseppe Di Mauro, Belen Ballesteros, Neus Lozano, Kostas Kostarelos, Loredana Casalis*, Laura Ballerini*

FULL ABSTRACT

Biomaterials, 2021, 271, 120749

Graphene oxide prevents lateral amygdala dysfunctional synaptic plasticity and reverts long lasting anxiety behavior in rats

Audrey F. Biagioni, Giada Cellot, Elisa Pati, Neus Lozano, Belén Ballesteros, Raffaele Casani, Norberto C. Coimbra, Kostas Kostarelos, Laura Ballerini*

FULL ABSTRACT

Small, 2020, 16 (48), 2004029

Intracerebral injection of graphene oxide nanosheets mitigates microglial activation without inducing acute neurotoxicity: A pilot comparison to other nanomaterials

Corinne Portioli, Cyrill Bussy*, Mariarosa Mazza, Neus Lozano, Dhifaf A. Jasim, Maurizio Prato, Alberto Bianco, Marina Bentivoglio, Kostas Kostarelos*

FULL ABSTRACT

FlatChem 2018, 12, 17-25

Graphene-based papers as substrates for cell growth: Characterisation and impact on mammalian cells

Dhifaf Jasim, Neus Lozano, Cyrill Bussy, Irina Barbolina, Artur Filipe Rodrigues, Kostya Novoselov, Kostas Kostarelos*

FULL ABSTRACT

2D Materials, 2018, 5, 035020

A blueprint for the synthesis and characterisation of thin graphene oxide with controlled lateral dimensions for biomedicine

Artur Rodrigues, Leon Newman, Neus Lozano, Sourav Mukherjee, Bengt Fadeel, Cyrill Bussy*, Kostas Kostarelos*

FULL ABSTRACT

Chem, 2018, 4 (2), 334-358

Graphene oxide elicits membrane lipid changes and neutrophil extracellular trap formation

Sourav Mukherjee, Beatrice Lazzaretto, Kjell Hultenby, Leon Newman, Artur Rodrigues, Neus Lozano, Kostas Kostarelos, Per Malmberg, and Bengt Fadeel*

FULL ABSTRACT

npj 2D Materials and Applications, 2017, 39

Hypochlorite degrades 2D graphene oxide sheets faster than 1D oxidised carbon nanotubes and nanohorns

Leon Newman, Neus Lozano, Minfang Zhang, Sumio Iijima, Masako Yudasaka, Cyrill Bussy* and Kostas Kostarelos*

FULL ABSTRACT

Advanced Healthcare Materials, 2017, 6 (21), 1700374

Liposome-indocyanine green nanoprobes for optical labelling and tracking of human mesenchymal stem cells post-transplantation in vivo

Mariarosa Mazza, Neus Lozano, Debora Braga Vieira, Maurizio Buggio, Cay Kielty, Kostas Kostarelos*

FULL ABSTRACT

PLoS One, 2016, 11 (11), e0166816

Detection of endotoxin contamination of graphene-based materials using the TNF-α expression test and guidelines for endotoxin-free graphene oxide production

Sourav Mukherjee, Neus Lozano, Melanie Kucki, Antonio E. Del Rio-Castillo, Leon Newman, Ester Vázquez, Kostas Kostarelos, Peter Wick, Bengt Fadeel*

FULL ABSTRACT

International Journal of Pharmaceutics, 2016, 514 (1), 133-141

Engineering thermosensitive liposome-nanoparticle hybrids loaded with doxorubicin for heat-triggered drug release

Zahraa Al-Ahmady^, Neus Lozano^, Kuo-Ching Mei^, Wafa’ T. Al-Jamal, Kostas Kostarelos*

FULL ABSTRACT

2D Materials, 2016, 3 (2), 025025

Purity of graphene oxide determines its antibacterial activity

Irina Barbolina, Colin Woods, Neus Lozano, Kostas Kostarelos, Konstantin Novoselov, Ian Roberts*

FULL ABSTRACT

ACS Nano, 2016, 10 (4), 4459-4471

Graphene oxide nanosheets reshape synaptic function in cultured brain networks

Rossana Rauti, Neus Lozano, Verónica León, Denis Scaini, Mattia Musto, Ilaria Rago, Francesco Paolo Ulloa Severino, Alessandra Fabbro, Loredana Casalis, Ester Vázquez, Kostas Kostarelos, Maurizio Prato, and Laura Ballerini*

FULL ABSTRACT

2D Materials, 2016, 3 (1), 01406

Synthesis of few-layered, high-purity graphene oxide sheets from different graphite sources for biology

Dhifaf A. Jasim, Neus Lozano, Kostas Kostarelos*

FULL ABSTRACT

International Journal of Pharmaceutics, 2015, 482, 2-10

Monoclonal antibody-targeted PEGylated liposome-ICG encapsulating doxorubicin as a potential theranostic agent

Neus Lozano, Zahraa S. Al-Ahmady, Nicolas S. Beziere, Vasilis Ntziachristos*, Kostas Kostarelos*

FULL ABSTRACT

Nanoscale, 2015, 7, 6432-6435

The current graphene safety landscape – a literature mining exercise

Cyrill Bussy, Dhifaf A. Jasim, Neus Lozano, Daniel Terry, Kostas Kostarelos*

FULL ABSTRACT

Biomaterials, 2015, 37, 415-424

Dynamic imaging of PEGylated indocyanine green (ICG) liposomes within the tumor microenvironment using multi-spectral optoacoustic tomography (MSOT)

Nicolas Beziere^, Neus Lozano^, Antonio Nunes, Juan Salichs, Daniel Queiros, Kostas Kostarelos*, Vasilis Ntziachristos*

FULL ABSTRACT