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The Nanomedicine Lab 2.0 Mission is to generate and disseminate fundamental knowledge in the field of nanomedicine by convergence of nanotechnology, bioengineering, pharmacology, neuroscience, cell biology, omics and their translation to advanced, clinically relevant and safe therapeutics and diagnostics

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RESEARCH TEAMS

The NanoOmics Team aims to harness the interactions of nanomaterials with blood components

The NanoInflammation Team studies how nanomaterials may cause inflammation or be used to modulate inflammation and control disease

The NanoCell Biology Team unveils interactions of nanomaterials with living cells and their structural compartments

The NanoNeuro Team studies the use of graphene-based neural interface technologies in the neurophysiology of brain disorders

The NanoTherapeutics Team exploits the unique properties of nanoparticles to develop clinically translatable advanced medicines

The Nanomedicine@ICN2 Team designs, fabricates and characterizes advanced nanomaterials at biological grade for medical use

RECENT PUBLICATIONSVIEW ALL

Nanoscale, 2023, in press, doi.org/10.1039/D2NR06753F

Correlative radioimaging and mass spectrometry imaging a powerful combination to study 14C-graphene oxide in vivo biodistribution

Hélène Cazier, Carole Malgorn, Dominique Georgin, Nathalie Fresneau, Fabrice Beau, Kostas Kostarelos, Cyrill Bussy, Stéphane Campidelli, Mathieu Pinault, Martine Mayne-L'Hermite, Frédéric Taran, Christophe Junot, François Fenaille, Antoine Sallustrau, Benoit Colsch

FULL ABSTRACT

Journal of Neuroscience, 2023, 43 (5): 685-692

Indirect effects of Halorhodopsin activation: potassium redistribution, non-specific inhibition and spreading depolarisation

R Ryley Parrish, Connie Mackenzie-Gray-Scott, Tom Jackson-Taylor, Alex Grundmann, Faye McLeod, Neela K Codadu, Alexandru Călin, Hannah Alfonsa, Rob C Wykes, Juha Voipio, Andrew J Trevelyan

FULL ABSTRACT

ACS Nano, 2023, in press

Graphene oxide nanosheets reduce astrocyte reactivity to inflammation and ameliorate experimental autoimmune encephalomyelitis

Graphene oxide nanosheets reduce astrocyte reactivity to inflammation and ameliorate experimental autoimmune encephalomyelitis

FULL ABSTRACT

Nature Nanotechnology, 2023, 18, 42–48

Graphene oxide elicits microbiome-dependent type 2 immune responses via the aryl hydrocarbon receptor

Guotao Peng, Hanna Sinkko, Harri Alenius, Neus Lozano, Kostas Kostarelos, Lars Bräutigam, Bengt Fadeel*

FULL ABSTRACT

Nanoscale, 2022, 14 (46): 17297-17314

Graphene oxide modulates dendritic cell ability to promote T cell activation and cytokine production

Helen Parker, Alfredo Gravagnuolo, Sandra Vranic, Livia Crica, Leon Newman, Oliver Carnell, Cyrill Bussy, Rebecca Dookie, Eric Prestat, Sarah Haigh, Neus Lozano, Kostas Kostarelos*, Andrew MacDonald*

FULL ABSTRACT

Advanced Healthcare Materials, 2022, 2201968

Graphene oxide nanoscale platform enhances the anti-cancer properties of bortezomib in glioblastoma models

Paul Sharp^, Maria Stylianou^, Luis Arellano, Juliana Neves, Alfredo Gravagnuolo, Abbie Dodd, Katharine Barr, Neus Lozano, Thomas Kisby*, Kostas Kostarelos*

FULL ABSTRACT

Methods in Molecular Biology, 2022, 2565, 13, 187-202

Membrane Capacitance Measurements of Stimulus-Evoked Exocytosis in Adrenal Chromaffin Cells

Elizabeth P. Seward, Robert C. Wykes

FULL ABSTRACT

ACS Appl. Nano Mater. 2022, 5 (9): 12626–12636

Effects of lateral size, thickness, and stabilizer concentration on the cytotoxicity of defect-free graphene nanosheets: implications for biological applications

Chen-Xia Hu, Oliver Read, Yuyoung Shin, Yingxian Chen, Jingjing Wang, Matthew Boyes, Niting Zeng, Adyasha Panigrahi, Kostas Kostarelos, Igor Larrosa, Sandra Vranic*, Cinzia Casiraghi*

FULL ABSTRACT

DMM Disease Models and Mechanisms, 2022, 15 (10): dmm049703

Targeting firing rate neuronal homeostasis can prevent seizures

Fred Mulroe, Wei-Hsiang Lin, Connie Mackenzie-Gray Scott, Najat Aourz, Yuen Ngan Fan, Graham Coutts, R Ryley Parrish, Ilse Smolders, Andrew Trevelyan, Rob Wykes, Stuart Allan, Sally Freeman, Richard Baines

FULL ABSTRACT

Particle and Fibre Toxicology, 2022, 19 (1), 1-21

Lung recovery from DNA damage induced by graphene oxide is dependent on size, dose and inflammation profile

Luis Augusto Visani de Luna, Thomas Loret, Alexander Fordham, Atta Arshad, Matthew Drummond, Abbie Dodd, Neus Lozano, Kostas Kostarelos and Cyrill Bussy

FULL ABSTRACT

RECENT NEWSVIEW ALL

29/10/2022

Aswin, Thomas and Cyrill contribute to Manchester’s ScienceX festival

21/10/2022

Rahaf presents at the Graphene Flagship WP4 meeting in Greece

Neus Lozano, team leader @ICN2, assists to the MINIGRAPH kick-off meeting

19/10/2022

Nanomedicine Lab @ICN2 receives the visit of Dr. Dhifaf Jasim

14/10/2022

Kostas is interviewed by Global Banking & Finance Review about smart materials and artificial intelligence are taking us closer to understanding the human brain

10/10/2022

Rob presents at the Co-Operative Studies on Brain Injury Depolarisations (COSBID) meeting in Salt Lake City, USA

06/10/2022

Hanan presented her project in the CRUK Radnet biannual meeting

03/10/2022

The Nanomedicine lab welcomes two new members in October

23/09/2022

RESEARCH TEAMS

RECENT PUBLICATIONSVIEW ALL

Correlative radioimaging and mass spectrometry imaging a powerful combination to study 14C-graphene oxide in vivo biodistribution

Indirect effects of Halorhodopsin activation: potassium redistribution, non-specific inhibition and spreading depolarisation

Graphene oxide nanosheets reduce astrocyte reactivity to inflammation and ameliorate experimental autoimmune encephalomyelitis

Graphene oxide elicits microbiome-dependent type 2 immune responses via the aryl hydrocarbon receptor

Graphene oxide modulates dendritic cell ability to promote T cell activation and cytokine production

Graphene oxide nanoscale platform enhances the anti-cancer properties of bortezomib in glioblastoma models

Membrane Capacitance Measurements of Stimulus-Evoked Exocytosis in Adrenal Chromaffin Cells

Effects of lateral size, thickness, and stabilizer concentration on the cytotoxicity of defect-free graphene nanosheets: implications for biological applications

Targeting firing rate neuronal homeostasis can prevent seizures

Lung recovery from DNA damage induced by graphene oxide is dependent on size, dose and inflammation profile

RECENT NEWSVIEW ALL

Aswin, Thomas and Cyrill contribute to Manchester’s ScienceX festival

Rahaf presents at the Graphene Flagship WP4 meeting in Greece

Neus Lozano, team leader @ICN2, assists to the MINIGRAPH kick-off meeting

Nanomedicine Lab @ICN2 receives the visit of Dr. Dhifaf Jasim

Kostas is interviewed by Global Banking & Finance Review about smart materials and artificial intelligence are taking us closer to understanding the human brain

Rob presents at the Co-Operative Studies on Brain Injury Depolarisations (COSBID) meeting in Salt Lake City, USA

Hanan presented her project in the CRUK Radnet biannual meeting

The Nanomedicine lab welcomes two new members in October

Kate was awarded the Céline Newman Neurobiology of Epilepsy Award by ERUK for presenting her work at the ILAE 2022 conference in Cardiff

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