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The Nanomedicine Lab 2.0 Mission is to generate and disseminate fundamental knowledge in the field of nanomedicine by convergence of nanotechnology, bioengineering, pharmacology, neuroscience, cell biology, omics and their translation to advanced, clinically relevant and safe therapeutics and diagnostics

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RESEARCH TEAMS

The NanoOmics Team aims to harness the interactions of nanomaterials with blood components

The NanoInflammation Team studies how nanomaterials may cause inflammation or be used to modulate inflammation and control disease

The NanoCell Biology Team unveils interactions of nanomaterials with living cells and their structural compartments

The NanoNeuro Team studies the use of graphene-based neural interface technologies in the neurophysiology of brain disorders

The NanoTherapeutics Team exploits the unique properties of nanoparticles to develop clinically translatable advanced medicines

The Nanomedicine@ICN2 Team designs, fabricates and characterizes advanced nanomaterials at biological grade for medical use

RECENT PUBLICATIONSVIEW ALL

Small, 2023, in press

Lung persistence, biodegradation and elimination of graphene based materials is predominantly size-dependent and mediated by alveolar phagocytes

Thomas Loret^, Luis Visani de Luna^, Matteo Lucherelli, Alexander Fordham, Neus Lozano, Alberto Bianco*, Kostas Kostarelos*, Cyrill Bussy*

FULL ABSTRACT

bioRxiv, 2023, doi: https://doi.org/10.1101/2023.03.30.534957

Functioning human lung organoids model pulmonary tissue response from carbon nanomaterial exposures

Rahaf Issa, Neus Lozano, Kostas Kostarelos, Sandra Vranic*

FULL ABSTRACT

Nanoscale, 2023, in press

Defect-free graphene enhances enzyme delivery to fibroblasts derived from the patients with lysosomal storage disorders

Yingxian Chen, Tooba Taufiq, Niting Zeng, Neus Lozano, Angeliki Karakasidi, Heather Church, Ana Jovanovic, Simon Jones, Adyasha Panigrahi, Igor Larossa, Kostas Kostarelos, Cinzia Casiraghi, Sandra Vranic*

FULL ABSTRACT

Nanoscale, 2023,15 (11): 5510-5518

Correlative radioimaging and mass spectrometry imaging a powerful combination to study 14C-graphene oxide in vivo biodistribution

Hélène Cazier, Carole Malgorn, Dominique Georgin, Nathalie Fresneau, Fabrice Beau, Kostas Kostarelos, Cyrill Bussy, Stéphane Campidelli, Mathieu Pinault, Martine Mayne-L'Hermite, Frédéric Taran, Christophe Junot, François Fenaille, Antoine Sallustrau, Benoit Colsch

FULL ABSTRACT

Journal of Neuroscience, 2023, 43 (5): 685-692

Indirect effects of Halorhodopsin activation: potassium redistribution, non-specific inhibition and spreading depolarisation

R Ryley Parrish, Connie Mackenzie-Gray-Scott, Tom Jackson-Taylor, Alex Grundmann, Faye McLeod, Neela K Codadu, Alexandru Călin, Hannah Alfonsa, Rob C Wykes, Juha Voipio, Andrew J Trevelyan

FULL ABSTRACT

ACS Nano 2023, 17 (3): 1965–1978

Graphene oxide nanosheets reduce astrocyte reactivity to inflammation and ameliorate experimental autoimmune encephalomyelitis

Giuseppe Di Mauro, Roberta Amoriello, Neus Lozano, Alberto Carnasciali, Daniele Guasti, Maurizio Becucci, Giada Cellot*, Kostas Kostarelos, Clara Ballerini*, Laura Ballerini*

FULL ABSTRACT

Nature Nanotechnology, 2023, 18 (1): 42-48

Graphene oxide elicits microbiome-dependent type 2 immune responses via the aryl hydrocarbon receptor

Guotao Peng, Hanna Sinkko, Harri Alenius, Neus Lozano, Kostas Kostarelos, Lars Bräutigam, Bengt Fadeel*

FULL ABSTRACT

Nanoscale, 2022, 14 (46): 17297-17314

Graphene oxide modulates dendritic cell ability to promote T cell activation and cytokine production

Helen Parker, Alfredo Gravagnuolo, Sandra Vranic, Livia Crica, Leon Newman, Oliver Carnell, Cyrill Bussy, Rebecca Dookie, Eric Prestat, Sarah Haigh, Neus Lozano, Kostas Kostarelos*, Andrew MacDonald*

FULL ABSTRACT

Advanced Healthcare Materials, 2022, 2201968

Graphene oxide nanoscale platform enhances the anti-cancer properties of bortezomib in glioblastoma models

Paul Sharp^, Maria Stylianou^, Luis Arellano, Juliana Neves, Alfredo Gravagnuolo, Abbie Dodd, Katharine Barr, Neus Lozano, Thomas Kisby*, Kostas Kostarelos*

FULL ABSTRACT

Methods in Molecular Biology, 2022, 2565, 13, 187-202

Membrane Capacitance Measurements of Stimulus-Evoked Exocytosis in Adrenal Chromaffin Cells

Elizabeth P. Seward, Robert C. Wykes

FULL ABSTRACT

THE NANOSEMINARS SERIES

GRID VIEW

14/07/2022

Flexible electronics for neural interfaces

Prof. Jonathan Viventi

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21/04/2022

The Robotics Part of Micro and Nano Robotics

Prof. Bradley Nelson

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10/03/2022

Barcoded Nanoparticles for Precision Cancer Medicine: Effects of tumor type and patient sex on anticancer efficacy

Prof. Avi Schroeder

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27/01/2022

Micro/Nano Engineering and Drug Delivery

Prof. Anja Boisen

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25/11/2021

Technology for Bioelectronic Medicine

Prof. George Malliaras

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14/10/2021

Translational research in organic neuroprosthetics

Prof. Diego Ghezzi

WATCH NOW

RECENT NEWSVIEW ALL

24/03/2023

Despoina and Neus visit Nanomedicine Lab in Manchester

08/03/2023

Cyrill attends PlasticHeal Anual Meeting in Wageningen, Holland

23/02/2023

Sandra presents at the 19th Annual Lysosomal Disorder Symposium in Florida, USA

01/02/2023

Welcome to our Master project students in the Nanomedicine Lab!

25/01/2023

Nanomediciners talk in the Advanced Materials in Medicine Conference

09/01/2023

Our start-up INBRAIN Neuroelectronics wins European Innovation Council Accelerator Award

03/01/2023

Press release and attention for our recent Nature Nanotechnology article

12/12/2022

Lana graduated with her PhD!

10/12/2022

RESEARCH TEAMS

RECENT PUBLICATIONSVIEW ALL

Lung persistence, biodegradation and elimination of graphene based materials is predominantly size-dependent and mediated by alveolar phagocytes

Functioning human lung organoids model pulmonary tissue response from carbon nanomaterial exposures

Defect-free graphene enhances enzyme delivery to fibroblasts derived from the patients with lysosomal storage disorders

Correlative radioimaging and mass spectrometry imaging a powerful combination to study 14C-graphene oxide in vivo biodistribution

Indirect effects of Halorhodopsin activation: potassium redistribution, non-specific inhibition and spreading depolarisation

Graphene oxide nanosheets reduce astrocyte reactivity to inflammation and ameliorate experimental autoimmune encephalomyelitis

Graphene oxide elicits microbiome-dependent type 2 immune responses via the aryl hydrocarbon receptor

Graphene oxide modulates dendritic cell ability to promote T cell activation and cytokine production

Graphene oxide nanoscale platform enhances the anti-cancer properties of bortezomib in glioblastoma models

Membrane Capacitance Measurements of Stimulus-Evoked Exocytosis in Adrenal Chromaffin Cells

THE NANOSEMINARS SERIES

Flexible electronics for neural interfaces

The Robotics Part of Micro and Nano Robotics

Barcoded Nanoparticles for Precision Cancer Medicine: Effects of tumor type and patient sex on anticancer efficacy

Micro/Nano Engineering and Drug Delivery

Technology for Bioelectronic Medicine

Translational research in organic neuroprosthetics

RECENT NEWSVIEW ALL

Despoina and Neus visit Nanomedicine Lab in Manchester

Cyrill attends PlasticHeal Anual Meeting in Wageningen, Holland

Sandra presents at the 19th Annual Lysosomal Disorder Symposium in Florida, USA

Welcome to our Master project students in the Nanomedicine Lab!

Nanomediciners talk in the Advanced Materials in Medicine Conference

Our start-up INBRAIN Neuroelectronics wins European Innovation Council Accelerator Award

Press release and attention for our recent Nature Nanotechnology article

Lana graduated with her PhD!

Nanomedicine Lab joins the Geoffrey Jefferson Brain Research Centre

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