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The Nanomedicine Lab 2.0 Mission is to generate and disseminate fundamental knowledge in the field of nanomedicine by convergence of nanotechnology, bioengineering, pharmacology, neuroscience, cell biology, omics and their translation to advanced, clinically relevant and safe therapeutics and diagnostics

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RESEARCH TEAMS

The NanoOmics Team aims to harness the interactions of nanomaterials with blood components

The NanoInflammation Team studies how nanomaterials may cause inflammation or be used to modulate inflammation and control disease

The NanoCell Biology Team unveils interactions of nanomaterials with living cells and their structural compartments

The NanoNeuro Team studies the use of graphene-based neural interface technologies in the neurophysiology of brain disorders

The NanoTherapeutics Team exploits the unique properties of nanoparticles to develop clinically translatable advanced medicines

The Nanomedicine@ICN2 Team designs, fabricates and characterizes advanced nanomaterials at biological grade for medical use

RECENT PUBLICATIONSVIEW ALL

Nature Reviews Chemistry, 2024, in press

The challenge and necessity of biological and environmental degradation for two-dimensional materials

Sandra Vranic^, Rajendra Kurapati^, Kostas Kostarelos*, Alberto Bianco*

FULL ABSTRACT

Nano Today, 2024, 56:102254

Functioning human lung organoids model pulmonary tissue response from carbon nanomaterial exposures

Rahaf Issa, Neus Lozano, Kostas Kostarelos, Sandra Vranic*

FULL ABSTRACT

Nature Reviews Materials, 2024, 1-4

In vivo biomolecule corona and the transformation of a foe into an ally for nanomedicine

Marilena Hadjidemetriou, Morteza Mahmoudi*, Kostas Kostarelos*

FULL ABSTRACT

Nature Nanotechnology, 2024, in press [https://doi.org/10.1038/s41565-023-01572-3]

First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses

Jack Andrews^, Shruti Joshi^, Evangelos Tzolos, Maaz Syed, Hayley Cuthbert, Livia Crica, Neus Lozano, Emmanuel Okwelogu, Jennifer Raftis, Lorraine Bruce, Craig Poland, Rodger Duffin, Paul Fokkens, John Boere, Daan Leseman, Ian Megson, Phil D. Whitfield, Kerstin Ziegler, Seshu Tammireddy, Marilena Hadjidemetriou, Cyrill Bussy, Flemming Cassee, David Newby, Kostas Kostarelos*, Mark Miller*

FULL ABSTRACT

Nanoscale, 2024, in press [https://pubs.rsc.org/en/content/articlehtml/2024/nr/d3nr06033k]

Graphene oxide activates canonical TGFβ signalling in a human chondrocyte cell line via increased plasma membrane tension

Leona Ogene, Steven Woods, Joseph Hetmanski, Neus Lozano, Angeliki Karakasidi, Patrick T. Caswell, Kostas Kostarelos, Marco Domingos, Sandra Vranic, Susan Kimber*

FULL ABSTRACT

ACS Nano, 2024, published online

Environmental and health impacts of graphene and other two-dimensional materials: a Graphene Flagship perspective

Hazel Lin, Tina Buerki-Thurnherr, Jasreen Kaur, Peter Wick, Marco Pelin, Aurelia Tubaro, Fabio Candotto Carniel, Mauro Tretiach, Emanuel Flahaut, Daniel Iglesias, Ester Vázquez, Giada Cellot, Laura Ballerini, Valentina Castagnola, Fabio Benfenati, Andrea Armirotti, Antoine Sallustrau, Mathilde Keck, Frédéric Taran, Cyrill Bussy, Sandra Vranic, Kostas Kostarelos, Mona Connolly, José Maria Navas, Florence Mouchet, Laury Gauthier, James Baker, Blanca Suarez-Merino, Tomi Kanerva, Maurizio Prato, Bengt Fadeel*, Alberto Bianco*

FULL ABSTRACT

Nature Reviews Electrical Engineering, 2024, in press

Clinical translation of graphene-based medical technology

Kostas Kostarelos, Carolina Aguilar, and Jose Garrido*

FULL ABSTRACT

Nature Nanotechnology 2024, in press [https://doi.org/10.1038/s41565-023-01570-5]

Nanoporous graphene-based thin-film microelectrodes for in vivo high-resolution neural recording and stimulation

Damià Viana^, Steven T. Walston^, Eduard Masvidal-Codina^, Xavier Illa, Bruno Rodríguez-Meana, Jaume del Valle, Andrew Hayward, Abbie Dodd, Thomas Loret, Elisabet Prats-Alfonso, Natàlia de la Oliva, Marie Palma, Elena del Corro, María del Pilar Bernicola, Elisa Rodríguez-Lucas, Thomas A. Gener, Jose Manuel de la Cruz, Miguel Torres-Miranda, Fikret Taygun Duvan, Nicola Ria, Justin Sperling, Sara Martí-Sánchez, Maria Chiara Spadaro, Clément Hébert, Sinead Savage, Jordi Arbiol, Anton Guimerà-Brunet, M. Victoria Puig, Blaise Yvert, Xavier Navarro, Kostas Kostarelos*, Jose A. Garrido*

FULL ABSTRACT

bioRxiv, 2024, doi.org/10.1101/2023.09.18.558196

Engineering the glioblastoma microenvironment using TLR7/8 agonist-complexed graphene oxide nanosheets

Maria Stylianou, Thomas Kisby*, Despoina Despotopoulou, Helen Parker, Alexandra Thawley, Kiana Arashvand, Neus Lozano, Andrew MacDonald, Kostas Kostarelos*

FULL ABSTRACT

ACS Nano, 2023, 17 (24): 24919–24935

Pulmonary toxicity of boron nitride nanomaterials is aspect ratio dependent

Luis Visani^, Thomas Loret^, Yilin He, Morgan Legnani, Hazel Lin, Anne Marie Galibert, Alexander Fordham, Sonja Holme, Antonio Castillo, Francesco Bonaccorso, Alberto Bianco*, Emmanuel Flahaut*, Kostas Kostarelos*, Cyrill Bussy*

FULL ABSTRACT

THE NANOSEMINARS SERIES

GRID VIEW

14/07/2022

Flexible electronics for neural interfaces

Prof. Jonathan Viventi

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21/04/2022

The Robotics Part of Micro and Nano Robotics

Prof. Bradley Nelson

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10/03/2022

Barcoded Nanoparticles for Precision Cancer Medicine: Effects of tumor type and patient sex on anticancer efficacy

Prof. Avi Schroeder

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27/01/2022

Micro/Nano Engineering and Drug Delivery

Prof. Anja Boisen

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25/11/2021

Technology for Bioelectronic Medicine

Prof. George Malliaras

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14/10/2021

Translational research in organic neuroprosthetics

Prof. Diego Ghezzi

WATCH NOW

RECENT NEWSVIEW ALL

07/02/2024

Welcome to Ms Despoina Politi, our new Erasmus student!

16/01/2024

Noelia and Kostas give talks at ICONAN 2024

07/10/2023

Sorayut visits the team at ICN2 from Manchester

15/09/2023

Despoina talks at NanoBio2023!

02/06/2023

Prof. Ben Feringa, Nobel Prize in Chemistry gives a lecture at ICN2

29/05/2023

Students from the Nanoscience & Nanotechnology UAB programme visit Nanomedicine Lab@ICN2

19/05/2023

Sam and Ahmed present at the Methods in Neuroscience seminar series

18/05/2023

NanoInflammation and NanoCell Biology Teams chair session and give talks at the Inhaled Particles and NanOEH Conference

09/05/2023

RESEARCH TEAMS

RECENT PUBLICATIONSVIEW ALL

The challenge and necessity of biological and environmental degradation for two-dimensional materials

Functioning human lung organoids model pulmonary tissue response from carbon nanomaterial exposures

In vivo biomolecule corona and the transformation of a foe into an ally for nanomedicine

First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses

Graphene oxide activates canonical TGFβ signalling in a human chondrocyte cell line via increased plasma membrane tension

Environmental and health impacts of graphene and other two-dimensional materials: a Graphene Flagship perspective

Clinical translation of graphene-based medical technology

Nanoporous graphene-based thin-film microelectrodes for in vivo high-resolution neural recording and stimulation

Engineering the glioblastoma microenvironment using TLR7/8 agonist-complexed graphene oxide nanosheets

Pulmonary toxicity of boron nitride nanomaterials is aspect ratio dependent

THE NANOSEMINARS SERIES

Flexible electronics for neural interfaces

The Robotics Part of Micro and Nano Robotics

Barcoded Nanoparticles for Precision Cancer Medicine: Effects of tumor type and patient sex on anticancer efficacy

Micro/Nano Engineering and Drug Delivery

Technology for Bioelectronic Medicine

Translational research in organic neuroprosthetics

RECENT NEWSVIEW ALL

Welcome to Ms Despoina Politi, our new Erasmus student!

Noelia and Kostas give talks at ICONAN 2024

Sorayut visits the team at ICN2 from Manchester

Despoina talks at NanoBio2023!

Prof. Ben Feringa, Nobel Prize in Chemistry gives a lecture at ICN2

Students from the Nanoscience & Nanotechnology UAB programme visit Nanomedicine Lab@ICN2

Sam and Ahmed present at the Methods in Neuroscience seminar series

NanoInflammation and NanoCell Biology Teams chair session and give talks at the Inhaled Particles and NanOEH Conference

Hanan talks at the Strategic Training in Transdisciplinary Radiation Science (STARS21), University of Toronto

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